GöTTINGEN, Germany -- Label IT® Nucleic Acid Labeling Reagents
Efficient, direct, non-enzymatic labeling of DNA and RNA

The Label IT® Technology is a non-enzymatic chemical labeling method that facilitates the direct covalent attachment of either fluorescent or non-fluorescent labels to any nucleic acid using a simple one-step chemical reaction. Mirus Bio optimized the Label IT® Technology for specialized applications including: FISH, microarrays, and nucleic acid visualization both in vitro and in vivo .

Highlights & Data

♦ Label Any DNA or RNA Template - Suitable for a wide range of applications.
♦ One-step Chemical Method - Easily and consistently control the labeling reactions.
♦ Adjustable Labeling Density - Achieve high sensitivity with optimally labeled DNA and RNA.
♦ Covalent Mechanism - Permanent, non-destructive modification of nucleic acid residues is ideal for many diverse applications; labels do not impact hybridization performance.

Available Label IT® Nucleic Acid Labeling Kits:
CX-Rhodamine
Fluorescein
Digoxin
Biotin
Cy®3
Cy®5
DNP
TM-Rhodamine

Kit Components:
Each Kit contains a Label IT® Reagent, Label IT® Reconstitution Solution, 10X Labeling Buffer and solutions.

NOTE: All the Label IT® Reagents use the same technology, but each attach different fluorophores with distinct excitation and emission spectra.

Displayed in Fig. 1:

The Label IT® chemical labeling reagents are composed of three regions: the label (fluorophore or hapten) (green), the linker (yellow) which facilitates electrostatic interactions with nucleic acids and the reactive alkylating group (blue) that covalently attaches the Label IT® reagent to any reactive heteroatom within the nucleic acids. Attachment of the Label IT® Reagents to nucleic acids does not alter the structure of the nucleic acid or affect downstream hybridization performance, and as such, nucleic acids labeled using the Label IT® Reagents can be employed in multiple applications as defined by the researcher.

MoBiTec offers the Label IT® Kits to its customer in Germany and some adjacent countries. Please check the link below for further details.

http://www.mobitec.com/cms/products/bio/07_fluores_tec/la...

MoBiTec GmbH (Goettingen, Germany) is a privately held company (founded in 1987) that offers research tools for molecular and cell biology. Products include DNA vectors for cloning and expression, cell transfection reagents and cell culture tools, immobilized and soluble enzymes, products for genomics and proteomics research, numerous antibodies and recombinant proteins, superior fluorescence reagents and kits, affinity chromatography products, as well as general laboratory equipment.

In parallel to its own product lines, MoBiTec distributes products from international companies in Germany. MoBiTec products are distributed worldwide, in Germany from their home office, in other countries by distributors.


Contact
MoBiTec GmbH