Promising research has found potential hope for cancer prevention and treatment in an unlikely and non-traditional approach -- a study of elephants and the surprising results may change the strategies used to treat cancer in the near future.
The progressive study, published in The Journal of the American Medical Association, JAMA, set out to identify mechanisms for cancer resistance in elephants and compare cellular response to DNA damage among elephants, healthy human controls and cancer-prone patients with Li-Fraumeni syndrome, LFS", according to the research objectives.
Researchers performed a comprehensive survey of data found in the autopsy records of 36 species in order to validate cancer resistance in the mammalians. They then took blood lymphocytes from a variety of elephants from differing regions, as well as healthy human participants and patients who had LFS and tested the samples in their lab to analyze DNA damage response from exposure to ionizing radiation and doxorubicin.
The outcome leads to optimism, with study results stating, Despite their large body size and long life span, elephants remain cancer resistant, with an estimated cancer mortality of 4.81% compared with humans, who have 11% to 25% cancer mortality."
Researchers believe the disparity found is due to the breakthrough discovery, While humans have 1 copy of TP53, African elephants have at least 20 copies". The study also noted the ways this discovery could influence the future of cancer research and treatment, These findings, if replicated, could represent an evolutionary-based approach for understanding mechanisms related to cancer suppression." The report added, Understanding the cellular mechanisms of cancer suppression in animals could benefit humans at high risk of cancer, such as patients with LFS, and even the health aging population."
These remarkable findings have spurred large amounts of interest in the natural health community. When asked for comment, a representative for a well known brand said Understanding how different biological forms deal with and protect themselves against cancer really opens up this field of research to a lot of possibilities. If this process can be understood and replicated in humans, we may be able to successfully prevent cancer in people from all walks of life. Now that would be a real breakthrough."
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